Relevance of GSTM 1 , GSTT 1 , and GSTP 1 gene polymorphisms to gastric cancer susceptibility and phenotype 771
نویسندگان
چکیده
Ma Asunción García-González1,2,*, Enrique Quintero3, Luis Bujanda4,2, David Nicolás3, Rafael Benito5,2, Mark Strunk1,2, Santos Santolaria6, Federico Sopeña7,2, María Badía7, Elizabeth Hijona4, Ma Angeles Pérez-Aísa8, Isabel Ma Méndez-Sánchez8, Concha Thomson9, Patricia Carrera2, Elena Piazuelo1,2, Pilar Jiménez2, Jesús Espinel10, Rafael Campo11, Marisa Manzano12, Fernando Geijo13, Maria Pellisé14,2, Ferrán González-Huix15, Jorge Espinós16, LLusia Titó17, Manuel Zaballa18, Roberto Pazo19 and Angel Lanas1,2,7
منابع مشابه
Glutathione S-transferase GSTM 1, null genotype may be associated with susceptibility to age-related cataract.
BACKGROUND Age-related cataract (ARC) is the leading cause of visual disability and reversible blindness all over the world. The different expressions of GST isozymes among animals may explain the variations in the cataract formation caused by oxidative stress. OBJECTIVES In this study, we evaluated the distribution of GST gene polymorphisms in ARC patients and the possible associations betwe...
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AIM We conducted a prospective study in an Chinese population to detect associations of GSTM, GSTT and GSTP polymorphisms with hepatocellular carcinoma (HCC), and analyze roles in determining survival outcome. METHODS A prospective follow-up study was conducted with 476 HCC patients and 481 controls collected from May 2005 to May 2007. All patients were followed up until the end of Dec. 2011....
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Background: Gastric cancer is one of the most common malignancies in the world. It may result from a defect in the genes involved in DNA repair. One of the essential genes in the repair pathway is the XRCC1 gene that its polymorphisms in the human population play a role in gastric cancer susceptibility. The main purpose of this study was to investigate the association of 194C/T and 399G/A polym...
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Background: North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds especially agricultural pesticides are massively used. Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics. The polymorphic nature of cyp2E1 gene control elements is associated with interindividual differences...
متن کاملGenetic susceptibility to oral cancer due to combined effects of GSTT1, GSTM1 and CYP1A1 gene variants in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa province of Pakistan.
Associations of GSTT1, GSTM1 and CYP1A1 gene variants with risk of developing oral cancer were evaluated in this study. A case-control study was conducted in Pashtun population of Khyber Pakhtunkhwa province of Pakistan in which 200 hospital based oral cancer cases and 151 population based healthy controls exposed to similar environmental conditions were included. Sociodemographic data were obt...
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تاریخ انتشار 2012